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Tamira (Levetiracetam)

Levetiracetam is an antiepileptic drug which acts by modulation (Inhibition) of synaptic neurotransmitter release through binding to the synaptic vesicle protein SV2A in the brain & also inhibits voltage-dependent calcium channels.

Tamira® indications

• Partial Onset Seizures
• Myoclonic Seizures In Patients with Juvenile Myoclonic Epilepsy
• Primary Generalized Tonic-Clonic Seizures
tamira product packing

Tamira® Dosage & Administration

Partial onset seizure
Age range Age > 16y 4y < Age < 16y 6m < Age < 4y 1m < Age < 6m
Initial Dosing 1000 mg/day, given as twice-daily dosing 20 mg/kg/day in 2 divided doses 20 mg/kg/day in 2 divided doses 14 mg/kg/day in 2 divided doses
Maintenance Dosing 1000 mg/day additional every 2 weeks, MRD*: dose of 3000 mg 20 mg/kg/day every 2 weeks to RDD* of 60 mg/kg (30 mg/kg twice daily) 20 mg/kg/day every 2 weeks to RDD* of 50 mg/kg (25 mg/kg twice daily) 14 mg/kg/day every 2 weeks to RDD* of 42 mg/kg (21 mg/kg twice daily)
Myoclonic Seizures in Patients with Juvenile Myoclonic Epilepsy
Initial Dosing 1000 mg/day, given as twice-daily dosing (500 mg twice daily)
Maintenance Dosing 1000 mg/day every 2 weeks to the RDD* of 3000 mg
Primary Generalized Tonic-Clonic Seizures
Age range Age > 16y 6y < Age < 16y
Initial Dosing 1000 mg/day, given as twice-daily 20 mg/kg/day  in 2 divided doses
Maintenance Dosing 1000 mg/day every 2 weeks to RDD* of 3000 mg 20 mg/kg (10 mg/kg twice daily) every 2 weeks to RDD* of 60 mg/kg (30 mg/kg twice daily)


MRD: Maximum Recommended Dose
RDD: Recommended Daily Dose
Diluents: Sodium chloride 0.9% solution for injection, Ringer's lactate solution for injection, Dextrose 5% solution for injection.

Tamira® (Levetiracetam) Dose Adjustments in Renal Impairment


Group Creatinine Clearance (mL/min/1.73m²) Dosage (mg) Frequency
Normal > 80 500 to 1,500 Every 12 hours
Mild 50 - 80 500 to 1,000 Every 12 hours
Moderate 30 - 50 250 to 750 Every 12 hours
Severe < 30 250 to 500 Every 12 hours
ESRD* patients using dialysis - 500 to 1,0001 Every 24 hours1
1 Following dialysis, a 250 to 500 mg supplemental dose is recommended

ESRD: End-Stage Renal Disease

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