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Teicomix (Teicoplanin)

Teicoplanin is a glycopeptide antibiotic used in the prophylaxis & treatment of serious infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis & clostridium difficile.

It's mechanism of action is to inhibit bacterial cell wall synthesis by inhibiting the formation of peptidoglycan.

Teicomix® indications:

  • Hospital acquired pneumonia & community acquired pneumonia - Infective endocarditis
  • Complicated skin & soft tissue infections
  • Bone & joint infections
  • Complicated urinary tract infections
  • Peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD)
  • As antimicrobial prophylaxis in orthopedic surgery at risk of Gram-positive infection (MRSA)
  • Bacteremia that occurs in association with any of the indications listed above
  • As alternative oral treatment for Clostridium difficile infection-associated diarrhea & colitis.
Teicomix package

dosing in adults and elderly patients with normal renal function

Indications Loading dose Maintenance dose
- Complicated skin and soft tissue infections - Pneumonia - Complicated urinary tract infections 6 mg/kg body weight every 12 hrs for 3 IV or IM administrations 6 mg/kg body weight IV or IM once a day
- Bone and joint infections 12 mg/kg body weight every 12 hrs for 3 to 5 IV administrations 12 mg/kg body weight IV or IM once a day
- Infective endocarditis 12 mg/kg body weight every 12 hrs for 3 to 5 IV administrations 12 mg/kg body weight IV or IM once a day
- Peritonitis for patients on continuous ambulatory peritoneal dialysis (CAPD) 6 mg/kg body weight IV as single injection first week: 20 mg/L in each dialysis bag second week: 20 mg/L in every other dialysis bag third week: 20 mg/L in the overnight dialysis bag
- Clostridium difficile infections 100 to 200 mg by mouth, twice a day for 7 to 14 days

Teicomix® dosing in babies & childrens

Age range Loading dose Maintenance dose
Babies (from birth to the age of 2 months) 16 mg/kg body weight as IV infusion through a drip, on the first day 8 mg/kg body weight as IV infusion through a drip once a day
Children (from 2 months to 12 years) 10 mg/kg body weight every 12 hrs IV administrations, repeated 3 times 6-10 mg/kg body weight IV administration, once a day

Specific advantages:

Teicoplanin Vs. Vancomycin
Characteristics Teicoplanin Vancomycin
Dosing frequency  Once daily(longer t1/2) More than once daily
Nephrotoxicity less more
Infusion time less more
Dose adjustment in renal dysfunction* Less needed-Simple  More needed-Difficult 
Dose adjustment in elderly population No Yes
Hypersensitivity reactions (red man syndrome) Less More
*In renal dysfunction, usual dose is used for first three days. After the fourth day of treatment: In mild and moderate renal insufficiency (creatinine clearance 30-80 mL/min): maintenance dose should be halved, either by administering the dose every two days or by administering half of this dose once a day. - In severe renal insufficiency (creatinine clearance less than 30 mL/min) and in haemodialysed patients: dose should be one-third the usual dose, either by administering the initial unit dose every third day or by administering one-third of this dose once a day.

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